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Translation of promising preclinical findings into clinical applications is crucial, as many studies have failed to demonstrate efficacy in clinical trials [123]

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In the trials themselves, discontinuation rates were modest and monitored: in Studies 2, 3 and 4, 16% of Wegovy-treated and 19% of placebo-treated patients discontinued therapy, with 6.8% of Wegovy-treated patients discontinuing due to an adverse reaction

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