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doi: 10.1007/s40266-021-00890-2 4 GretenFRGrivennikovSI

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Patients should contact their GP within a few days if they experience persistent symptoms that, whilst less acute, may indicate liver dysfunction: Ongoing fatigue or weakness that interferes with daily activities Loss of appetite extending beyond the expected appetite suppression from the medication Persistent nausea or vomiting that prevents adequate nutrition or hydration New or worsening abdominal swelling It is important to distinguish between expected side effects and potential liver problems