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Most people tolerate NMN well, but some may experience mild side effects, particularly when first starting supplementation

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Among them, SANs and High-Entropy Nanozymes (HEzymes) offer two highly promising strategies

Accordingly, administration of milrinone, a PDE III inhibitor, to Wistar rats before noise over-exposure, ameliorates vacuolization, inflammation, and apoptotic processes in the sensory epithelium and the SV as compared to untreated rats (Ceylan et al., The micronutrient Mg 2+ also has been proposed as a treatment for NIHL, not only for its function as a potential cochlear vasodilator but for other pharmacological properties, which include modulation of NMDA glutamate receptors and the regulation of calcium influx into hair cells, preventing or reducing apoptosis (Cevette et al., 2+ for one month enhanced hair cell survival and reduced significantly the auditory threshold shift in noise-exposed guinea pigs (Abaamrane et al., 2+ alone 1 h before and up to 5 days after noise stimulation in guinea pigs, did not show reliable effects over noise over-exposure

Greenberger, University of Pittsburgh Medical Center-Shadyside, USA Copyright 2014 Aquilano, Baldelli and Ciriolo