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Dan Buettner, the author of Blue Zones, said he liked Outlive and thought the science was sound, but he was skeptical because it requires a person who is two or three standard deviations from the norm when it comes to discipline, income, and presence of mind. In Austin, Attia told me that one of the biggest aha moments of his professional life was realizing that centenarians last as long as they do because favorable genetic profiles tend to keep chronic disease at bay
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NTR1 agonists can exert neuroprotective effects and improve cognitive function by alleviating excessive microglial activation and inhibiting oxidative stress, cell apoptosis, and synaptic loss in the hippocampus [67, 68]