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Within this framework: HRT supports neural bioenergetics and mitochondrial stability, helping sustain adequate energy supply GLP-1 therapies reduce systemic and central inflammatory stress, improving the environment in which neurons function Rather than acting in isolation, these therapies may operate synergistically to stabilize both energy production and stress response systems within the brain

doi:10.1111/j.1651-2227.1992.tb12085.x [62] Flanagan JL, Simmons PA, Vehige J, Willcox MD, Garrett Q

Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRI

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