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Pharmacokinetics Once-weekly dosing via C20 fatty diacid albumin binding

Common side effects include nausea, vomiting, diarrhea, and constipation, with potential serious risks including pancreatitis and gallbladder disease

Antioxidant & Cellular Support ALA is commonly recognized for its antioxidant-supporting properties

This work was supported by the Japan Society for the Promotion of Science KAKENHI (21H04811 and 22K19405), AMED (JP23ek0109521), Daiichi Sankyo Foundation of Life Science, The NOVARTIS Foundation (Japan) for the Promotion of Science and G-7 Scholarship Foundation

The first-line treatment is rigorous daily sun protection and the association of tinted sunscreen with topical bleaching agents, which may have a different action on melanogenesis