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Beyond cardiovascular health, Aon observed that female GLP-1 users had an approximately 50 percent lower incidence rate for ovarian cancer and 14 percent lower incidence of breast cancer compared to matched female non-users

Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin and IGF-1 levels and increased lifespan

Duration Limitations: The longest safety data extends to 24 weeks

In Cleveland Clinic's 2025 analysis of real-world use, semaglutide 2.4 mg produced mean weight loss of approximately 14.1% at one year versus the ~15% trial number, and tirzepatide produced approximately 16.5% versus the 22% trial number

The role of microbiome in insomnia, circadian disturbance and depression