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Impaired methylation can lead to elevated homocysteine concentrations and altered DNA methylation, both of which have been associated with an increased risk of cardiovascular disease, neurological disorders, and other chronic health conditions

Conflict of interest The author is an advisor to several regulatory agencies and governments

China has the most individuals with type 2 diabetes, while the US has the second most

This property makes GFAP a valuable marker of astrogliosis according to immunohistochemistry, a phenomenon that occurs in brains subjected to neuronal loss and vascular and microvascular changes [42]

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