We also translate the cardiovascular story into human termswhy some large trials found fewer heart attacks and strokes and give a reality-check on the brain research so you know whats hopeful and whats hype
Escalation for subjects receiving tirzepatide comprise a dosing schedule initiated with 2.5mg dose per week for 4 weeks, and increasing by 2.5 mg increments, such that subjects receive a once weekly dose that is 2.5mg (4 weeks), 5mg (4 weeks), 7.5mg (4 weeks), 10mg (4 weeks), 12.5mg (4 weeks), 15mg (4 weeks)
doi:10.1016/j.clnu.2020.07.019 Wilding JPH, Batterham RL, Calanna S, et al
You're committing to giving the protocol a fair trial, not to a contractual obligation
Furthermore, there is a small increase in metabolism, specifically resting metabolic rate (RMR), and demand for calories during the two weeks leading up to menstruation, which may cause women to experience increased cravings (17)