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Indeed, iGPX4 may be a promising target for NAFLD therapy as activated iGPX4 interacts with the canonical cGPX4 by transforming cGPX4 from enzymatically active monomers to enzymatically inactive oligomers in response to lipid stress, which exacerbates ferroptosis (Tong et al., 2022)

469 Finally, two recent studies have demonstrated that two surrogate markers of oxidative stress, oxLDL 470 and plasmalogen 471 were associated with increased cardiovascular mortality in patients with advanced CKD

Working alongside the nervous and immune systems, the endocrine system ensures the body can respond effectively to various stresses and changes

"GLP-1 Diet: Foods to Eat and Avoid on Weight Loss Medication." March 2025

10.3390/ijms251910786 [DOI] [PMC free article] [PubMed] 31.Fan H, Gong N, Li TF, Ma AN, Wu XY, Wang MW, Wang YX (2015) The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating beta-endorphin release from spinal microglia