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Strikingly, the study revealed that the immune cells of these patients act as an "energy sink." In a desperate attempt to survive the overwhelming oxidative stress, the immune cells upregulate their own intracellular glutathione production
Adv Clin Chem
Vy glutathione l g
Bax, a pro-apoptotic Bcl-2 family protein, resides in the cytoplasm and translocates to the mitochondria in response to apoptotic stimuli, where it facilitates the release of Cyt C (Shalini et al., 2015)
The free radical theory and the mitochondrial theory propose that elevated free radicals (oxidative stress) and mitochondrial dysfunction, respectively, are at the core of geriatric aging
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