it's documented here rather than silently picked for you
Semaglutide has been undetectable in human milk samples, and NIH LactMed reports tirzepatide is usually undetectable at doses up to 5 mg, suggesting potential infant exposure is low based on limited data., What is known vs unknown about GLP-1 medications in breast milk Known: Semaglutide has been undetectable in small human milk studies Tirzepatide is usually undetectable in limited LactMed summaries GLP-1 medications are large peptide molecules with poor oral absorption Unknown: Long-term infant health or developmental outcomes Effects on milk supply or milk composition Safety in newborn or preterm infants Scientific explanation peptide size and oral bioavailability GLP-1 receptor agonists are large peptide molecules with high molecular weight, which limits their ability to diffuse from maternal blood into breast milk. In addition, peptide drugs have poor oral bioavailability, meaning that even if small amounts are ingested, systemic absorption by the infant is unlikely., Plain-English explanation why the babys stomach offers protection GLP-1 medications are peptide-based and must be injected because the stomach destroys them
Using the Ala 28 from GIP may decrease affinity with GLP-1R and increase the activities of the two receptors in vitro, but it is likely to decrease these activities in vivo
NAD and MNM, crucial for energy metabolism and cell repair, restore energy production and DNA repair, combating the age-related decline in NAD levels
Someone buying a GLP-1 drug directly for weight loss might pay about the same, or more, depending on which service they choose and whether it offers more support beyond just a prescription
