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The FDA-approved indications for cervical TDR are for single-level disease without significant facet disease and are primarily indicated for disc herniation with nerve root compression

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More recently, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) RAs have transformed pharmacologic management by producing greater, more durable weight loss and meaningful cardiometabolic benefits

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