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Here we review receptor biology and coactivator coupling, the pharmacology of SLU-PP-332 in cells and animals, dosing paradigms and route considerations used in published studies, translational biomarkers and experimental endpoints, context-dependent risks and unknowns, and practical guidance for nonclinical study design

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Likewise, MPTP is metabolized into the toxic cation 1-methyl-4-phenylperydinium (MPP + ) [156] by the enzyme MAO-B of glial cells, specifically astrocytes, provides that high-affinity for MPP + affects dopamine transporter (DAT)