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Basatemur GL, Jrgensen HF, Clarke MCH, Bennett MR, Mallat Z

Molecular Metabolism, 57, 101351

The medication slows gastric emptying, causing food to remain in the stomach longer and triggering gastrointestinal symptoms

The compound emerged from Eli Lilly's incretin research program, which has produced a progression of increasingly complex agonists over two decades: dulaglutide (single GLP-1 receptor agonist), tirzepatide (dual GLP-1/GIP receptor agonist), and now Retatrutide (triple GLP-1/GIP/glucagon receptor agonist)