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Furthermore, the most radioresistant NSCLC cell model NCI-H1299 showed elevated ser/gly production, reflected as the accumulation of labeled m + 3 serine and m + 2 glycine, in response to irradiation (Supplementary Fig

This shortage of key TCA cycle metabolites in patient NPs was accompanied by a ~3050% reduction in the total NAD pool and the NAD/NADH ratio (Figs