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Consistently, electrophysiological recordings showed that liraglutide increases the EPSCs frequency of POMC neurons suggesting the modulation of presynaptic excitatory synaptic transmission (He et al., 2019)

Ablation of the PPG neurons in the NTS largely reduces the level of GLP-1 in the hypothalamus, brainstem, and spinal cord (Holt et al., 2019)

All existing research has been conducted in mice, with no long-term human safety trials and no established safe doses for humans

Published findings include: Clean endocrine profile (no significant ACTH/cortisol/prolactin spike) GH peak at approximately 40 minutes post-injection Return to baseline within 3 hours No significant hunger stimulation (unlike GHRP-6)

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