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This is because prostaglandins, which are blocked by COX inhibition, are important for proper blood vessel function within the kidneys (Ejaz 2004)

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However, the reason these trials did not employ a true nutrient synergy design was likely in order to build upon previous evidence indicating these individual nutrients provided a benefit for the same endpoint or had a similar mechanism

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The oxidized ASC (DHA) can further produce various metabolites by AOs under plant apoplastic conditions