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Conversely, other studies have demonstrated that lactic acid may partially restore PGC-1 activity, reduce the expression of pro-inflammatory cytokines including TNF-, IL-1, and IL-6, alleviate renal injury, and improve survival in murine models of sepsis-induced AKI (Takakura and Zandi-Nejad, 2019)

Hyperacetylation of H3 promotes the transcription of pro-inflammatory genes, whereas hypoacetylation of H4 suppresses the expression of anti-inflammatory genes ( 3.2.4 PBMCs PBMCs are a heterogeneous population of immune-competent cells in peripheral blood, including monocytes, T cells, B cells, and other cell types