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After stopping a CYP3A4 inhibitor, as the effects of the inhibitor decline, the hydrocodone plasma concentration will decrease (see CLINICAL PHARMACOLOGY), resulting in decreased opioid efficacy or a withdrawal syndrome in patients who had developed physical dependence to hydrocodone bitartrate and acetaminophen tablets

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doi: 10.1126/science.1098014 6 AndreassiC.AngelozziC.TizianoF

The duration of the result is also influenced by lifestyle and sun exposure habits

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