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Cardiovascular disease and CKD In 2024, semaglutide was approved by the FDA as the first weight-loss medication to reduce the risk of major adverse cardiovascular events (MACE) in adults with obesity or who are overweight, without T2D and stablished CVD, when prescribed with a reduced-calorie diet and increased physical activity

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Neurodegenerative diseases T2D is a risk factor for cognitive dysfunction and for developing Alzheimers disease (62)

Pancreatic islets were isolated as previously described 17 from mice killed by terminal decapitation and the peritoneal cavity exposed