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Even if the main folate receptors are blocked by antibodies, leucovorin can enter the central nervous system through the reduced folate carrier (RFC) , essentially bypassing the roadblock at the FR [4]
Mar 14 2019;3(3):CD007411
Jacque, N
7 This is a reasonable commercial and clinical strategy the combination is where the largest benefit lies but it means that the specific scientific question in this articles title has, somewhat ironically, been left partly in shadow by the very success of the combination program
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