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The standard approach involves starting at the lowest dose and gradually increasing every 4 weeks to minimize side effects

For day 2, eat scrambled eggs with spinach for breakfast and turkey lettuce wraps for lunch

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This pace was enabled by several factors: the strength and consistency of the Phase 2 efficacy signals, Eli Lilly's extensive infrastructure for metabolic disease trials built through the tirzepatide program, the availability of well-characterized biomarkers and endpoints for obesity and diabetes, and the increasing regulatory receptivity to obesity treatments as the field matured

The FDA determined that the tirzepatide shortage was resolved on December 19, 2024, following reevaluation