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The binding of a ligand to a TLR causes adaptor moleculessuch as myeloid differentiation primary response 88 (MyD88), Toll/IL-1 receptor (TIR) domain-containing adaptor protein (TIRAP), TIR domain-containing adaptor-inducing interferon- (TRIF), and TRIF-related adaptor molecule (TRAM)to bind the TIR domain of the receptor
36 That overlap gives us a reason to look for drugs that might protect the brain across multiple diseases
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Its clinical trial participants lost an average of 20% of their body weight within a year and a half of starting treatment
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