Researchers comparing the two in a laboratory setting must account for the half-life differences
However, any claims that IGF-1 can promote weight loss are largely theoretical, or based on animal studies and small human studies (14)
A retrospective analysis in an American population with T2DM found that GLP-1RA usage was associated with a significantly lower risk of stroke than DPP4i
However, some studies indicate an increased risk of fractures, possibly due to weight loss-associated reductions in bone mineral density (BMD)
Machiraju, P., Wang, X., Sabouny, R., Huang, J., Zhao, T., Iqbal, F., King, M., Prasher, D., Lodha, A., Jimenez-Tellez, N., Ravandi, A., Argiropoulos, B., Sinasac, D., Khan, A., Shutt, T