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Cell 180 , 373386 (2020)

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[14] Because the liver is the central organ of copper handling and a major site of oxidative stress during injury, a copper-carrying, antioxidant-supporting peptide has a plausible mechanistic story there but the data are old, experimental, and not human, and the founding observation that the same peptide stimulates growth in neoplastic liver cells is a reminder that acts on the liver is not synonymous with good for the liver in every context