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Bipolar disorder: A landmark RCT (n=75) found that NAC (1,000 mg twice daily for 24 weeks) produced a significant improvement in depression scores (Montgomery-Asberg Depression Rating Scale) in bipolar disorder as an adjunct to usual treatment (Berk et al., Biol Psychiatry, 2008) [74]

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We think that, considering the level of efficacy associated to the excellent safety profile, CoQ10 should be the first line treatment in patients in whom the initial evaluation did not find anxiety or clear dysautonomic signs

Due to the higher availability of L-carnitine, CAR may have an adequate flux of L-carnitine and acylcarnitine in PBMC during LPS-induced inflammation and may not need to adapt by upregulating SLC25A20 in PBMC