Lactate is produced: As you exercise, your muscles break glucose down into lactic acid
Hyperglycemia inhibits hepatic production of Sex Hormone Binding Globulin (SHBG), which leads to an increase of free androgens in the blood circulation, and insulin resistance increases the production of androgens by the theca cells
Moreover, evidence has emerged that a link exists between glutathione (GSH) metabolism and the epigenetic regulation of redox phenomena 3,4
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Astroglial pathophysiology is complex, with different pathophysiological cell states and cell phenotypes that are context-specific and vary with disorder, disorder-stage, comorbidities, age, and sex