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Creatinine clearance was measured by 24hour urinary creatinine clearance measurements or estimated from serum creatinine based on the CockcroftGault formula: CrCl = [140 - age (years)] x weight (kg) [72 x serum creatinine (mg/dL)] Compared to normal healthy control subjects, an approximate 1.1- to 1.6-fold increase in plasma AUC of sitagliptin was observed in patients with mild renal insufficiency

For mild symptoms, contact a doctor to discuss next steps

administer slowly over 515 minutes Patient education note: transient garlic-like taste or smell during infusion is normal and benign a sulfur metabolism effect that resolves when the push is complete

Plant-based choices such as tofu, lentils, and other legume options add protein along with fiber, which can support digestion and fullness

Those with pre-existing kidney disease require particular caution with magnesium supplementation due to reduced renal excretion and hypermagnesaemia risk