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Medicine 100:e24845

The EMA and FDA have approved several drugs in this class of medication for the treatment of T2D including dapagliflozin, empagliflozin, canagliflozin and ertugliflozin

The question that matters clinically is whether a given patient is a good candidate, what the right protocol looks like for their specific goals and lab results, and whether they have access to a supervised framework that can catch the small number of patients for whom these compounds are not appropriate before they start rather than after

T., Schachter, S., & Rotenberg, A

Well basically, you can uncouple that charge and so that positive charge protons start leaking out the mitochondria and your mitochondria freak out