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ii) Cardiovascular death: Excluding the SOUL trial strengthened the effect (shifting from non-significant to significant), suggesting sensitivity to SOUL but moderate robustness due to consistent overall effect direction and magnitude

This matters because even a one-unit error at high concentrations translates to meaningful dose differences

We also know that even though the WHI focused on long-term HRT use for chronic disease prevention in women over age 60, the results were generalized to younger women who were using short-term HRT to manage midlife symptoms like hot flashes, not to prevent disease