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In addition, an overexpression of soluble Klotho (sKlotho) protein which inhibits the function of IGF-1 receptor (IGF-1R) (Fig

nutraceuticals (preferably, in the form of polypills containing several natural substances with proven effect on LDL-C [135]), low-dose statin (with LDL-C reduction up to 30%), or ezetimibe (in case of statin intolerance), and if this is not effective, a combination of these therapies

As your body begins burning stored fat for fuel, you may notice mild fatigue until your metabolism stabilizes

Preclinical studies suggested that GLP-1RAs reduced immune cell activity and oxidative stress in kidney and led to decrease in fibrosis [15, 45]

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