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Diabetes 69 , 313330 (2020)

Since the N atom of His 54 is distant from the C2 atom of the caddie Tyr 98 (4.2 , S1E Fig), the residue is unlikely to act as a base

The molecular-level understanding of OA pathogenesis has led to the identification of major catabolic enzymes, ADAMTS5 76 , MMP3 77 , and MMP13 78 , which mediate the degradation of cartilage matrix