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Once a peptide degrades, its efficacy is diminished or completely lost

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It emphasizes the importance of individualized treatment plans, considering factors such as patient preferences, potential side effects, and overall health

Only through such systematic and in-depth inquiry can clinically feasible and individually tailored therapeutic strategies be developed, thereby offering novel scientific avenues for the preservation of male fertility

In particular, Eadesgroup in 2011 identified and validated for the first time in MDA-MB-231 and Hs578T breast cancer cells a miRNA, miR-200a, able to target the KEAP1 3-untranslated region (3-UTR), leading to KEAP1 mRNA degradation and, consequently, NRF2 stabilization and translocation to the nucleus [178]