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Daily exposure to UV rays, pollution, stress, and natural aging slows down the skins repair cycle, leading to dullness, uneven tone, fine lines, and loss of firmness

Given the increasing use of GLP-1 RAs among women of childbearing potential and the lack of standardized guidance, this review synthesizes current evidence on their pharmacokinetics, safety in preconception and early pregnancy, and clinical management strategies

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While tirzepatide has yet to demonstrate direct cardiovascular risk outcomes in patients without type 2 diabetes, tirzepatide-treated groups did demonstrate reductions in cardiometabolic variables resulting in a significantly lower 10-year predicted ASCVD risk in patients with overweight or obesity without type 2 diabetes in post hoc analysis of the SURMOUNT-1 trial [49]

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