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Criado M., Hernndez-Martn E

Therefore, p53 is an important therapeutic target for keloids because of its crucial role in regulating apoptosis 7,8

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Compared with normal skin fibroblasts, a greater number of keloid fibroblasts displayed a senescent phenotype and were arrested at the G0/G1 phase using a serum-limited culture approach, indicating the senescent tendency of keloid fibroblasts under simulated ischemic stress