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Primers for amplicon preparation are listed in Supplementary Table 5

Receptor Pathway Comparison This dual incretin research peptide shares the same receptor targets (GLP-1R + GIPR) as Tirzepatide (LY3298176), the FDA-approved twincretin compound studied extensively in metabolic research

Metabolic Benefits Beyond weight loss, GLP-1 medications improve metabolic health by: Lowering blood sugar levels Enhancing insulin sensitivity Reducing risk factors for cardiovascular disease These effects make GLP-1 therapy particularly beneficial for patients with obesity-related conditions such as type 2 diabetes or metabolic syndrome

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The effect is sharpest during aerobic exercise, where fat is already the body's primary fuel source