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When a leaky gut is present, intestinal barrier permeability is increased, pro-inflammatory substances like LPS may activate inflammatory pathways, be recognized and activated by the TLR4 receptor, and mediate inflammatory responses

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R., Gargari, B

In vivo and in vitro enhanced tumoricidal effects of metformin, active vitamin D3, and 5-fluorouracil triple therapy against colon cancer by modulating the PI3K/Akt/PTEN/mTOR network

Journal of physiology and biochemistry, 74 (1), 189-193