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The first seven trials involved patients with T2DM and baseline glycated hemoglobin levels ranging from 7.3 to 8.7, whereas the most recent SELECT trial focused on nondiabetic patients with overweight or obesity and preexisting cardiovascular disease

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Together, molecular clocks, neural circuits, and hormonal signals form an integrated neuroendocrinecircadian axis that coordinates physiological homeostasis and modulates stress responses

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Intraocular Pressure As increased intraocular pressure is an integral feature of ischemic retinal damage in rats, we measured intraocular pressure using a calibrated applanation tonometer