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Interestingly, there exists a close interplay for the underlying cause that foster neurodegenerative disease and metabolic disorders, such that CBD may represent an innovative therapy to treat cognitive loss that is tied to metabolic disease (Fig

Therefore, riboflavin deficiency will lead to the downregulation of GSH and oxidative stress, which is the predominant cause for reduced osteogenic capacities of BMSCs and enhanced osteoclastic potentials of osteoclast precursors [54, 55], finally leading to net bone loss

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Therapeutic recombinant FGFs or biologically active derivatives could potentially be used to enhance the regenerative potential of muscle by increasing satellite cell number

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