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The G150 series compounds targeting the ATP/GTP-binding pockets of human cGAS demonstrate potent inhibitory activity in THP-1 cells [413], and compound S3, identified through molecular dynamics simulations and virtual screening, exhibits a mechanism of action analogous to PF-069282155 [414]
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Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases