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Modifications can be made to the termini of existing CPPs or the peptide backbone can be adjusted, such as through peptide cyclization, to improve stability and cell permeability

Glatter: In practice, many patients labeled non-responders to GLP-1 therapy are experiencing incomplete dosing, early discontinuation because of gastrointestinal side effects, insufficient treatment duration, or competing metabolic drivers such as severe insulin resistance, sleep disruption, sarcopenia, or medication-associated weight gain