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Here, we assessed GLP-1R expression by immunohistochemistry (IHC) in 576 patient NENs of diverse origin and determined sensitivity to semaglutide using novel patient-derived NET spheroids

Breastfeeding is not recommended during trial participation

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Calcium imaging studies in GnRH-expressing cell lines reveal altered intracellular calcium dynamics following clomiphene treatment, suggesting modulation of calcium-dependent exocytosis mechanisms underlying GnRH release

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