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In addition, studies are investigating their broader benefits in patients with chronic kidney disease (CKD) and in elderly populations, with the aim of improving overall health outcomes in these high-risk groups Table 3

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For example, the mutation of a highly conserved serine residue in the MBL of monovalent metal specific regulators to a cysteine, based on its presence in divalent metal regulators, resulted in variants capable of sensing both Hg II as well as the monovalent coinage metals (Figure 24B)