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Profound sedation, respiratory depression, coma, and death may result from the concomitant use of hydrocodone bitartrate and acetaminophen tablets with benzodiazepines and/or other CNS depressants, including alcohol [e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids]

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In contrast, ferroptosis inhibition via iron chelation or lipid radical scavenges blocked this Hmox1 activation-induced cardiac damage, supporting a ferroptosis targeting therapeutic strategy to alleviate cardiomyopathy in SCD 46