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The injection regimen did not impair adherence or cause significant withdrawal during treatment or run-in

Animal studies Six-week-old C57BL/6J mice were obtained from The Jackson Laboratory and bred under standard conditions with a 12-h light/dark cycle

The melanocortin system serves as a critical regulator at the intersection of multiple physiological processes including energy homeostasis, inflammation, immune responses, and behavioral functions

They are not recommended during pregnancy

The pharmacokinetic profile of semaglutide has been established based on subcutaneous delivery, which allows for gradual absorption and sustained therapeutic effect over several days, with a long half-life of approximately one week