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Although not definitively causal, these findings support the biological concern that exogenous antioxidants may attenuate ROS-mediated cytotoxic mechanisms induced by chemotherapy and radiotherapy, potentially reducing treatment efficacy

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The enzyme active site is accessible via two openings: a cleft between the propeller and hydrolase domains (Figure 4, Upper) and funnel located in the center of the -propeller domain (Figure 4, Lower) (Rasmussen et al., 2002)

These medications slow gastric emptying as part of their mechanism to reduce appetite and food intake

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