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It causes a narrowing in the spaces encompassing the neurovascular structures of the spine, leading to the characteristic clinical syndrome of buttock and bilateral lower extremity pain that may include the lower back

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Injection-site reactions Generally well-tolerated in published Phase 1/2 data No IGF-1 elevation (key distinction from rhGH or GH-axis peptides) Known interactions No major drug-drug interactions documented in published data Contraindications Pregnancy/lactation (unstudied) Hypersensitivity REGULATORY STATUS FDA Not FDA-approved

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