doi: 10.1016/j.jep.2021.113828 32 WuYHuYHaiyanZYunLinWXincongKDongboL
This glucagon-like peptide-1 (GLP-1) agonist has been hailed as a game changer due to its properties and significant clinical benefits
Mechanistically, the metabolic benefits of Godex depend on enhanced activity of CrAT, which modulates mitochondrial acetyl-CoA metabolism and thereby improves insulin sensitivity and hepatic lipid homeostasis (33)
Glycemic control appears to be more effective when both receptors are activated [99, 100]
[63] encompassing 1895 patients with T2DM reported a greater reduction in HbA1c, body weight, FPG, systolic blood pressure, BMI, and low-density lipoprotein cholesterol in a combination therapy group, compared to monotherapy with either GLP-1RA or SGLT-2i