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The findings from these studies and others will provide critical evidence on the optimization of timing, dosing, and safety, as well as greater insights into target populations for maximum benefit in prevention and treatment of AD

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Under hyperglycemic conditions, endothelial cells produce elevated levels of O 2 - .[77] Overproduction of O 2 - can inhibit glyceraldehyde-3-phosphate dehydrogenase which is an important enzyme of the glycolytic pathway.[78] This leads to the accumulation of glucose and other intermediate metabolites of this pathway and shifts to other alternative pathways of glucose metabolism along with increased production of advanced glycation end products

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doi: 10.1001/jamasurg.2025.3590